The 21 people who put their famous faces to work for this issue say it all.

The world is failing millions of children, especially in Africa," says Queen Rania Al-Abdullah, who is on the board of GAVI (Global Alliance for Vaccines and Immunization) Fund and was named Eminent Advocate for Children by UNICEF. "Lack of access to vaccines means that the world loses over two million children every year," she says. "We can save them all. These statistics belong to the children of the developing world, the heartbreak belongs to their parents, but the responsibility belongs to us all." Queen Rania is also an active advocate for micro-financing through FINCA International.

also other covers include, Bono, George Clooney, Jay-Z, Alicia Keys, Iman, Oprah, Madonna, Bill Gates, Brad Pitt, and others.